主任委员:顾怀宇

顾怀宇，中西医融合发展专业委员会，现任中山大学医学院教授，硕士、博士研究生导师。于1999年获佳木斯医学院人体解剖学硕士学位；于2002年获中山大学人体解剖学博士学位；于2002-2009年在美国加州大学欧文分校医学院人体解剖学与神经生物学从事博士后研究，曾任资深项目科学家；于2009年作为中山大学“百人计划”引进人才回国工作，在中山大学中山医学院任教。

顾怀宇教授自幼浸润在中医药文化中，曾得到过胡海牙等多名著名老中医的传授和指导。对传统医学和互补医学有独到的见解，并应用这一思想治疗各种疑难杂症，均取得显效。著有《万病一治论》，该著作被业内誉为医养之经典。

顾怀宇教授攻读医学博士期间，师从我国著名神经科学家姚志彬教授，并在苏国辉院士、吴武田教授的悉心指导下，在2002年首次发现了成人脑内Nestin免疫阳性细胞的分布，进一步证实了成人脑内存在可再生神经环路的学说。目前，人脑内干细胞的存在已被业内学者广泛证实。该发现以《Distribution of nestin immunoreactivity in the normal adult human forebrain.》为题在著名神经科学杂志《Brain Research》上发表，截至目前该文章他引频次已高达100余次；博士后期间，受到美国HHMI教授Diane K.O’Dowd的悉心指导。留学美国期间，原创性研发果蝇中枢神经系统单细胞膜片钳记录系统，成为人类历史上探测到活体全脑单细胞电活动的第一人，此成果在《Journal of Neuroscience》上发表，题为《Cholinergic synaptic transmission in adult Drosophila Kenyon cells in situ.》，并于2004年在《The Scientists》上接受发表题为《Probing the Mind of Drosophila》的专题报道，在国内外神经科学界引起了广泛关注。该发现通过神经电生理记录，建立起神经遗传学与神经行为学之间的桥梁。2012年-2016年，顾怀宇教授团队利用计算机虚拟筛选技术对靶向脑内特定受体的中草药单体、活性短肽进行了大量分子对接，经过数亿次的计算、筛选及实验验证，在《Neurotherapeutics》发表题为《EGAR, A Food Protein-Derived Tetrapeptide, Reduces Seizure Activity in Pentylenetetrazole-Induced Epilepsy Models Through α-Ami-no-3-Hydroxy-5-Methyl-4-Isoxazole Propionate Receptors》的文章；在探索阿尔兹海默症治疗新思路的过程中，发现传统中药水飞蓟宾具有良好的抗老年痴呆的功效，后在国际权威杂志《Neurobiology of Aging》杂志上发表论文《Silibinin inhibits acetylcholines-terase activity and amyloid β peptide aggregation: a dual-target drug for the treatment of Alzheimer’s disease》，为老年痴呆的中医药治疗开创了新方法、新思路。同期，顾怀宇教授在《瞭望东方》周刊中进行了一系列关于大健康的讨论，著有《中医药现代化的曙光》、《解决塑化剂风波的曝光》、《转基因食品的辩证法》和《改善记忆的新武器》等多篇社论性科普文章，向十八大献礼，为当前大健康理论的产生与发展奠定了充分的理论研究基础。2014年12月5日，《南方日报》以《光生物安全的国际标准将被改写》为题，特别报道了顾教授团队在以光子治疗老年痴呆过程中做出的杰出贡献。2016年至2017年期间，顾怀宇教授团队与浙江工商大学饶平凡教授团队合作，从啮齿类动物和灵长类动物等不同层次上探究超氧自由基的体内分布规律与中医经典经络系统的关系，取得重大发现。近年来，顾怀宇教授团队发表SCI论文40余篇，承担科研项目多项，包括国家自然科学基金面上项目与重点项目、科技部“863计划”项目及省部级项目等，科研经费愈千万。今年，顾怀宇教授荣获“托马斯·苏德霍夫人类大脑基金会特别贡献奖”，此奖项由2013年诺贝尔生理学或医学奖获得者Thomas C. Sdhof授予，全球仅有十名优秀神经科学家受此殊荣。

已发表SCI论文：

1. Huang H, Li P, Zhang M, Yu Y, Huang Y, Gu H, Wang C, Yang Y. Graphene quantum dots for detecting monomeric amyloid peptides. Nanoscale. 2017; 9(16):5044-5048.

2. Li K, Zhong X, Yang S, Luo Z, Li K, Liu Y, Cai S, Gu H, Lu S, Zhang H, Wei Y, Zhuang J, Zhuo Y, Fan Z, Ge J. HiPSC-derived retinal ganglion cells grow dendritic arbors and functional axons on a tissue-engineered scaffold. Acta Biomater. 2017; 54:117-127. 

3. Cai S, Ling C, Lu J, Duan S, Wang Y, Zhu H, Lin R, Chen L, Pan X, Cai M, Gu H. EGAR, A Food Protein-Derived Tetrapeptide, Reduces Seizure Activity in Pentylenetetrazole-Induced Epilepsy Models Through α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionate Receptors. Neurotherapeutics. 2017; 14(1):212-226. 

4. Sun X, Ran D, Zhao X, Huang Y, Long S, Liang F, Guo W, Nucifora FC Jr, Gu H, Lu X, Chen L, Zeng J, Ross CA, Pei Z. Melatonin attenuates hLRRK2-induced sleep disturbances and synaptic dysfunction in a Drosophila model of Parkinson's disease. Mol Med Rep. 2016; 13(5):3936-44. 

5. Yang J, Qi F, Gu H, Zou J, Yang Y, Yuan Q, Yao Z. Neonatal BCG vaccination of mice improves neurogenesis and behavior in early life. Brain Res Bull. 2016; 120:25-33.

6. Li Q, Qi F, Yang J, Zhang L, Gu H, Zou J, Yuan Q, Yao Z. Neonatal vaccination with bacillus Calmette-Guérin and hepatitis B vaccines modulates hippocampal synaptic plasticity in rats. J Neuroimmunol. 2015;288:1-12. Biomaterials. 2015; 53:184-201. 

7. Xu Y, Yan Y, He M, Liao Z, Ran D, Sun X, Liu Y, Wang X, Huang Y, Xu H, Gu H. A giant local interneuron modulates the rhythmic activities of the antennal lobe in Pupae Drosophila. Neurosci Lett. 2015; 606:82-7. 

8. Zeng X, Qiu XC, Ma YH, Duan JJ, Chen YF, Gu HY, Wang JM, Ling EA, Wu JL, Wu W, Zeng YS. Integration of donor mesenchymal stem cell-derived neuron-like cells into host neural network after rat spinal cord transection. Biomaterials. 2015; 53:184-201.

9. Wang F, He H, Zhuang H, Xie X, Yang Z, Cai Z, Gu H, Zhou J. Controlled light field concentration through turbid biological membrane for phototherapy. Biomed Opt Express. 2015; 6(6):2237-45.

10. Duan S, Guan X, Lin R, Liu X, Yan Y, Lin R, Zhang T, Chen X, Huang J, Sun X, Li Q, Fang S, Xu J, Yao Z, Gu H. Silibinin inhibits acetylcholinesterase activity and amyloid β peptide aggregation: a dual-target drug for the treatment of Alzheimer's disease. Neurobiol Aging. 2015; 36(5):1792-807. 

11. Chen R, Zhang T, Kuang L, Chen Z, Ran D, Niu Y, Xu K, Gu H. Cholinergic synaptic transmissions were altered after single sevoflurane exposure in Drosophila pupa. Biomed Res Int. 2015; 2015:485709. 

12. Shan Z, Cai S, Zhang T, Kuang L, Wang Q, Xiu H, Wen J, Gu H, Xu K. Effects of sevoflurane on leucine-rich repeat kinase 2-associated Drosophila model of Parkinson's disease. Mol Med Rep. 2015; 11(3):2062-70. 

13. Xiao Y, Fu H, Han X, Hu X, Gu H, Chen Y, Wei Q, Hu Q. Role of synaptic structural plasticity in impairments of spatial learning and memory induced by developmental lead exposure in Wistar rats. PLoS One. 2014; 9(12):e115556.

14. Qiao J, Zou X, Lai D, Yan Y, Wang Q, Li W, Deng S, Xu H, Gu H. Azadirachtin blocks the calcium channel and modulates the cholinergic miniature synaptic current in the central nervous system of Drosophila. Pest Manag Sci. 2014; 70(7):1041-7. 

15. Guo KH, Li DP, Gu HY, Jie-Xu, Yao ZB. Postnatal development of nestin positive neurons in rat basal forebrain: different onset and topography with choline acetyltransferase and parvalbumin expression. Int J Dev Neurosci. 2014; 35:72-9.

16. Yu ZL, Qiu S, Chen XC, Dai ZH, Huang YC, Li YN, Cai RH, Lei HT, Gu HY. Neuroglobin-a potential biological marker of retinal damage induced by LED light. Neuroscience. 2014; 270:158-67. 

17. Li X, Duan S, Chu C, Xu J, Zeng G, Lam AK, Zhou J, Yin Y, Fang D, Reynolds MJ, Gu H, Jiang L. Melaleuca alternifolia concentrate inhibits in vitro entry of influenza virus into host cells. Molecules. 2013; 18(8):9550-66.

18. Yan Y, Xu Y, Deng S, Huang N, Yang Y, Qiu J, Liu J, Wang X, Yang G, Gu H. A pair of identified giant visual projection neurons demonstrates rhythmic activities before eclosion.Neurosci Lett. 2013; 550:156-61.

19. Guan X, Yang J, Gu H, Zou J, Yao Z. Immunotherapeutic efficiency of a tetravalent Aβ1-15 vaccine in APP/PS1 transgenic mice as mouse model for Alzheimer's disease. Hum Vaccin Immunother. 2013; 9(8):1643-53.

20. Huang N, Yan Y, Xu Y, Jin Y, Lei J, Zou X, Ran D, Zhang H, Luan S, Gu H. Alumina nanoparticles alter rhythmic activities of local interneurons in the antennal lobe of Drosophila. Nanotoxicology. 2013; 7(2):212-20. 

21. Lai BQ, Wang JM, Duan JJ, Chen YF, Gu HY, Ling EA, Wu JL, Zeng YS. The integration of NSC-derived and host neural networks after rat spinal cord transection. Biomaterials. 2013; 34(12):2888-901.

22. Fang L, Duan J, Ran D, Fan Z, Yan Y, Huang N, Gu H, Zhu Y. Amyloid-β depresses excitatory cholinergic synaptic transmission in Drosophila. Neurosci Bull. 2012; 28(5):585-94.

23. Guan X, Zou J, Gu H, Yao Z. Short amyloid-β immunogens with spacer-enhanced immunogenicity without junctional epitopes for Alzheimer's disease immunotherapy. Neuroreport. 2012; 23(15):879-84. 

24. Duan J, Li W, Yuan D, Sah B, Yan Y, Gu H. Nitric oxide signaling modulates cholinergic synaptic input to projection neurons in Drosophila antennal lobes. Neuroscience. 2012; 219:1-9. 

25. Ran D, Cai S, Wu H, Gu H. Di (2-ethylhexyl) phthalate modulates cholinergic mini-presynaptic transmission of projection neurons in Drosophila antennal lobe. Food Chem Toxicol. 2012; 50(9):3291-7. 

26. Zhu J, Gu H, Yao Z, Zou J, Guo K, Li D, Gao T. The nestin-expressing and non-expressing neurons in rat basal forebrain display different electrophysiological properties and project to hippocampus. BMC Neurosci. 2011; 12:129.

27. Yang Y, Yan Y, Zou X, Zhang C, Zhang H, Xu Y, Wang X, Janos P, Yang Z, Gu H. Static magnetic field modulates rhythmic activities of a cluster of large local interneurons in Drosophila antennal lobe. J Neurophysiol. 2011; 106(5):2127-35. 

28. Ren P, Zhang H, Qiu F, Liu YQ, Gu H, O'Dowd DK, Zhou QY, Hu WP. Prokineticin 2 regulates the electrical activity of rat suprachiasmatic nuclei neurons. PLoS One. 2011; 6(6):e20263. 

29. Yan Y, Yang Y, You J, Yang G, Xu Y, Huang N, Wang X, Ran D, Yuan X, Jin Y, Fan Y, Lei J, Li W, Gu H. Permethrin modulates cholinergic mini-synaptic currents by partially blocking the calcium channel. Toxicol Lett. 2011; 201(3):258-63. 

30. Deng J, Wen Y, Wang C, Pan S, Gu H, Zeng X, Han L, Zhao Y, Feng M, Wu C. Efficient intracellular gene delivery using the formulation composed of poly (L-glutamic acid) grafted polyethylenimine and histone. Pharm Res. 2011; 28(4):812-26. 

31. Guo KH, Zhu JH, Yao ZB, Gu HY, Zou JT, Li DP. Chemical identification of nestin-immunoreactive neurons in the rat basal forebrain: a re-examination. Neurochem Int. 2010; 56(5):694-702.

32. Gu H, Jiang SA, Campusano JM, Iniguez J, Su H, Hoang AA, Lavian M, Sun X, O'Dowd DK. Cav2-type calcium channels encoded by cac regulate AP-independent neurotransmitter release at cholinergic synapses in adult Drosophila brain. J Neurophysiol. 2009; 101(1):42-53. 

33. Sheeba V, Gu H, Sharma VK, O'Dowd DK, Holmes TC. Circadian- and light-dependent regulation of resting membrane potential and spontaneous action potential firing of Drosophila circadian pacemaker neurons. J Neurophysiol. 2008; 99(2):976-88. 

34. Sheeba V, Sharma VK, Gu H, Chou YT, O'Dowd DK, Holmes TC. Pigment dispersing factor-dependent and -independent circadian locomotor behavioral rhythms. J Neurosci. 2008; 28(1):217-27.

35. Gu H, O'Dowd DK. Whole cell recordings from brain of adult Drosophila. J Vis Exp. 2007; (6):248. 

36. Hilgenberg LG, Su H, Gu H, O'Dowd DK, Smith MA. Alpha3 Na⁺/K⁺-ATPase is a neuronal receptor for agrin. Cell. 2006; 125(2):359-69.

37. Gu H, O'Dowd DK. Cholinergic synaptic transmission in adult Drosophila Kenyon cells in situ.

J Neurosci. 2006; 26(1):265-72.

38. Gu HY, Chai H, Zhang JY, Yao ZB, Zhou LH, Wong WM, Bruce IC, Wu WT. Survival, regeneration and functional recovery of motoneurons after delayed reimplantation of avulsed spinal root in adult rat. Exp Neurol. 2005; 192(1):89-99.

39. Gu HY, Chai H, Zhang JY, Yao ZB, Zhou LH, Wong WM, Bruce I, Wu WT. Survival, regeneration and functional recovery of motoneurons in adult rats by reimplantation of ventral root following spinal root avulsion. Eur J Neurosci. 2004; 19(8):2123-31.

40. Wu W, Chai H, Zhang J, Gu H, Xie Y, Zhou L. Delayed implantation of a peripheral nerve graft reduces motoneuron survival but does not affect regeneration following spinal root avulsion in adult rats. J Neurotrauma. 2004; 21(8):1050-8.

41. Gu H, Wang S, Messam CA, Yao Z. Distribution of nestin immunoreactivity in the normal adult human forebrain. Brain Res. 2002; 943(2):174-80.